THE DEFINITIVE GUIDE TO HAASS

The Definitive Guide to haass

The Definitive Guide to haass

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Together with an inter­dizipli­nary team he uncov­ered the molec­u­lar mecha­nisms of Alzheimer's disease and identi­fied target molecules for thera­peu­tic treatment.

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Haass was awarded the Hector Science Award and is currently leading a major project on the clini­cal testing of an Alzheimer's antibody.

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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects.  Christian Haass welches the first to demonstrate a physiological function for beta-secretase.  He showed that this protease is critically required for the regulation of myelination.  Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors.  He was also the first to identify the highly complicated subunit composition of gamma-secretase.  All these findings not only helped to understand several signaling pathways critically involved Weiterlesen in brain development (such as myelination and cell differentiation) but also provided the basis for several current therapeutic approaches.

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